Fungsi Vitamin D Terhadap Sistem Imun Penderita Rinitis Alergi

Abstrak

ABSTRAK

Rinitis alergi (RA) adalah gangguan simptomatik pada hidung yang diinduksi setelah paparan alergen melalui inflamasi yang diperantarai IgE pada selaput yang melapisi hidung. RA adalah masalah kesehatan global yang menyebabkan penyakit utama dan kecacatan di seluruh dunia, mempengaruhi kehidupan sosial, tidur, dan kinerja penderita. Dalam penelitian baru-baru ini, vitamin D yang merupakan hormon steroid memiliki peranan dalam perkembangan penyakit alergi. Vitamin D mempengaruhi baik imunitas bawaan maupun adaptif dan hampir semua jenis sel imunologi, termasuk sel T, B, dan dendritik. Selain itu, monosit dan makrofag dipengaruhi oleh regulasi 1,25 (OH)2D. Selain efeknya pada sel imun dengan memodulasi berbagai sitokin, vitamin D mungkin memiliki peran kunci dalam patogenesis banyak gangguan alergi.

ABSTRACT

Allergic rhinitis (AR) is a symptomatic disorder of the nose induced after allergen exposure through IgE-mediated inflammation of the membranes lining the nose. AR is a global health problem that causes major illness and disability worldwide, affecting patients’ social life, sleep, and their school and work performance. Vitamin D which is a member of the steroid hormones family has recently been mentioned in several studies regarding its role in the development of allergic diseases. Vitamin D affects both innate as well as adaptive immunity and almost all types of immunologic cells, including T, B, and dendritic cells. Moreover, monocytes and macrophages are influenced by the regulation of 1,25 (OH)₂D. In addition to its effects on immune cells by modulating a variety of cytokines, vitamin D may have a key role in the pathogenesis of many allergic disorders.